Cystatin C is a cysteine protease inhibitor, widely present in nucleated cells and body fluids of various tissues, and is a low molecular weight, basic non-glycated protein. Cystatin C in the circulation is only cleared by glomerular filtration, which is an endogenous marker reflecting the change of glomerular filtration rate, and is reabsorbed in the proximal convoluted tubule, but is completely absorbed after reabsorption. Metabolism is decomposed and does not return to the blood. Therefore, its blood concentration is determined by glomerular filtration and does not depend on any external factors, such as the influence of gender, age, and diet. It has been recommended internationally as a reflection of glomerular filtration. Ideal indicator of rate change.
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