ACE2, also known as ACEH, is called angiotensin-converting enzyme 2. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidase, and has considerable homology with human angiotensin-converting enzyme 1. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9 and angiotensin II into the vasodilator angiotensin 1-7. ACE2 has strong affinity for Ang II type 1 and type 2 receptors and regulates blood pressure, fluid balance, inflammation, cell proliferation, hypertrophy and fibrosis. At the same time, the organ- and cell-specific expression of this gene suggests that it may play a role in regulating cardiovascular and renal function and fertility. In addition, the protein encoded by this gene is a functional receptor for the S-glycoprotein of SARS and HCoV-NL63 human coronaviruses.
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