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What SARS-CoV-2 Changes in Your Body's Architecture

What SARS-CoV-2 Changes in Your Body's Architecture

  • Time of issue:2023-04-13
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(Summary description)This study not only helps to explain the immunological symptoms of SARS-CoV-2 infection in humans, but also explains the cause of "Long COVID-19".

What SARS-CoV-2 Changes in Your Body's Architecture

(Summary description)This study not only helps to explain the immunological symptoms of SARS-CoV-2 infection in humans, but also explains the cause of "Long COVID-19".

  • Categories:Blogs
  • Author:
  • Origin:
  • Time of issue:2023-04-13 16:55
  • Views:
Information

Recently, a scientific team from the University of Texas Health Science Center at Houston published an article in Nature Microbiology: "SARS-CoV-2 restructures host chromatin architecture". The study reveals a unique mechanism by which SARS-CoV-2 can have a serious impact on human health: infection with SARS-CoV-2 may change the genomic architecture of human cells. This change has never been found in other coronaviruses before. This study not only helps to explain the immunological symptoms of SARS-CoV-2 infection in humans, but also explains the cause of "Long COVID-19".

 

SARS-CoV-2 restructures host chromatin architecture

 

The genetic material in human cells is stored in chromatin structures. Previous studies have suggested that some viruses can hijack or alter human chromatin to successfully reproduce in cells, but whether and how SARS-CoV-2 affects chromatin in the human body has been an unsolved mystery. In the latest study, scientists used three-dimensional genomic techniques to comprehensively characterize the structure of chromatin within human cells after infection with SARS-CoV-2.

 

SARS-CoV-2 reorganizes the host 3D genome

SARS-CoV-2 reorganizes the host 3D genome

 

Recent studies have found that infection with SARS-CoV-2 deforms much of the otherwise well-structured chromatin within normal cells. For example, when humans are infected with SARS-CoV-2, the yin and yang parts of a chromatin structure called the a/B region begin to mix together, and this mixing may lead to changes in some key genes within infected cells, including the key inflammatory gene interleukin-6, which causes a cytokine storm in SARS-CoV-2 pneumonia patients with severe disease.

 

It was also found that SARS-CoV-2 also altered chromatin chemical modifications. Changes in chromatin chemical modifications are known to have long-term effects on gene expression and phenotype. Therefore, the new findings may provide a new perspective for understanding the effect of SARS-CoV-2 on host chromatin, which may be associated with "Long COVID-19".

 

According to the U.S. Centers for Disease Control and Prevention, nearly 1 in 5 Americans infected with SARS-CoV-2 pneumonia continue to have symptoms months after recovering from an acute infection. Researchers hope the latest findings pave the way for more research to understand the long-term effects of COVID-19.

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