The soluble growth-stimulated expression gene 2 protein (ST2), a member of the interleukin 1 receptor family, is available in both trans-model (ST2L) and soluble (sST2) forms. sST2L binds to the functional ligand IL-33 and has a protective effect on the heart, while elevated levels of sST2 in the blood can competitively bind IL-33 and block the IL-33/ST2L signaling pathway, thereby attenuating the systemic biological effects of IL-33. Thus, the systemic biological effects of IL-33 are diminished. Therefore, the presence of excessive sST2 may leave the myocardium without adequate protection against injury, leading to myocardial remodeling and dysfunction.

1. Ordering Information

1) ST2 Test Kit

2) ST2 Raw Materials

2. Performance Data

1) Linear Range: For the ST2 test kit; R2=0.9999≥0.99 in the range of 0.5–400 ng/mL.

2) Clinical Correlation: Comparison with Critical Diagnostics for clinical correlation, R2 > 0.96.

3) Minimum Detection Limit: The minimum detection limit of ST2 was calculated to be 0.000489 ng/mL ≤ 0.1 ng/mL.

4) Repeatability: The reproducibility CV of samples with different concentrations of ST2 was ≤ 8%.

5) Precision: The accuracy deviation of ST2 is within ±15%.

6) Stability (ST2 Test Kit): The relative deviation of 7-day thermal stability at different concentration points of the test is within ±5%, and the linearity of accelerated 7-day R2 = 0.9999 ≥ 0.99.

3. Advantages of ST2

1) A new generation heart failure marker with low biological variability and high stability.

2) Not interfered by age, gender, race, kidney function, body mass index and other influencing factors.

3) Single threshold value: 35ng/ml, the possibility of heart failure below 35ng/ml is very small.

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