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AIVD successfully developed a 25-OH-D assay with a clinical compound rate of >95%

AIVD successfully developed a 25-OH-D assay with a clinical compound rate of >95%

  • Time of issue:2022-10-19
  • Views:

(Summary description)25-OH-D plays an important physiological role in osteoporosis, rickets, chronic kidney disease (CKD) and skin diseases, especially in the regulation of calcium and phosphorus metabolism and maintenance of bone health, while its role in muscle, cardiovascular disease, diabetes, cancer, autoimmune and inflammatory responses is also gaining attention.

AIVD successfully developed a 25-OH-D assay with a clinical compound rate of >95%

(Summary description)25-OH-D plays an important physiological role in osteoporosis, rickets, chronic kidney disease (CKD) and skin diseases, especially in the regulation of calcium and phosphorus metabolism and maintenance of bone health, while its role in muscle, cardiovascular disease, diabetes, cancer, autoimmune and inflammatory responses is also gaining attention.

  • Categories:News
  • Author:AIVD
  • Origin:
  • Time of issue:2022-10-19 16:14
  • Views:
Information

There are about 40 kinds of detectable vitamin D metabolites in the body, among which 25-OH-D is the most present metabolite in circulation and the main form of vitamin D (VD) in the circulation, which can reflect the nutritional level of vitamin D in the body. Although the last biologically active form in the human body is 1,25(OH)2D, which is formed through hepatic and renal metabolism, it is not recommended for clinical evaluation due to its rapid metabolism and significantly lower level than 25-OH-D. Therefore, serum 25-OH-D levels are used internationally as an indicator of whether the body is deficient in VD.

 

25-OH-D plays an important physiological role in osteoporosis, rickets, chronic kidney disease (CKD) and skin diseases, especially in the regulation of calcium and phosphorus metabolism and maintenance of bone health, while its role in muscle, cardiovascular disease, diabetes, cancer, autoimmune and inflammatory responses is also gaining attention.

 

25-OH-D

 

Clinical applications of 25-OH-D assay:

 

01 Guiding early clinical prevention and treatment of osteoporosis

To provide theoretical support for the rational and standardized clinical use of vitamin D therapy.

 

02 Diagnosis of early pediatric rickets

Serum 25-OH-D is the main diagnostic basis for vitamin D insufficiency, mild vitamin D deficiency, and early rickets.

 

03 Maternity examination of pregnant women

The management of pregnancy is beneficial in preventing the development and progression of related pregnancy complications and reducing the occurrence of adverse pregnancy outcomes.

 

04 Vitamin D and hypertension

Studies have shown that for every 10% increase in body vitamin D concentration, the risk of developing hypertension decreases by 8%.

 

 

AIVD has successfully developed a 25-OH-D assay with a clinical compound rate of >95%.

 

  1. Product Information

Product Name

Catalog #

Linear Range

Correlation

Detection Limit

Specimen

25-OH-D Detection Uncut Sheet (FIA)

IF25DB

5-70ng/mL

R2>0.99

R2>0.95

4ng/mL

Serum/plasma

 

  1. Linear Range: R² > 0.99 for the kit in the range of 5-70 ng/mL

25-OH-D Linear Range

 

  1. Clinical correlation: R² > 0.95 for clinical correlation between the kit and Roche.

25-OH-D Correlation

 

  1. Precision: The precision CV of the test high, medium and low concentration points are all ≤ 8%.

25-OH-D Precision

 

  1. Stability: The relative deviation of thermal stability for 16 days at different concentration points is within ±8%.

25-OH-D Stability

 


 

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